File Name: exercise and type 2 diabetes .zip
Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.
Obesity and T2DM are associated with diminished glucose uptake in the brain that impairs the satiating effect of dietary carbohydrate; therefore, carbohydrate restriction might help maintain weight loss and maximize metabolic benefits.
Likewise, increases in physical activity and fitness are an important contributor to T2DM remission when combined with calorie restriction and weight loss. Preliminary studies suggest that a precision dietary management approach that uses pretreatment glycaemic status to stratify patients can help optimize dietary recommendations with respect to carbohydrate, fat and dietary fibre.
This approach might lead to improved weight loss maintenance and glycaemic control. Future research should focus on better understanding the individual response to dietary treatment and translating these findings into clinical practice. Studies show that weight loss can produce remission of type 2 diabetes mellitus T2DM in a dose-dependent manner. Long-term maintenance of weight loss and metabolic health in people who have undergone intensive lifestyle intervention is challenging.
When combined with calorie restriction and weight loss, increases in physical activity and fitness are an important contributor to T2DM remission. Preliminary work suggests that pretreatment glycaemic status could be used to stratify patients in order to optimize dietary recommendations.
International Diabetes Federation. Zhu, Y. Diabetes Care 42 , — Magkos, F. A review of the dissociation between excess body weight and metabolic dysfunction. Willett, W.
Guidelines for healthy weight. Prospective Studies Collaboration. Body-mass index and cause-specific mortality in , adults: collaborative analyses of 57 prospective studies. Lancet , — Chan, J. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 17 , — Colditz, G. Weight gain as a risk factor for clinical diabetes mellitus in women.
Hu, F. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. Kendall, D. Clinical application of incretin-based therapy: therapeutic potential, patient selection and clinical use. Mittendorfer, B. Relationship between body fat mass and free fatty acid kinetics in men and women. Obesity 17 , — Conte, C. Multiorgan insulin sensitivity in lean and obese subjects. Diabetes Care 35 , — Wilman, H. Characterisation of liver fat in the UK Biobank cohort. PLoS One 12 , e Pienkowska, J.
MRI assessment of ectopic fat accumulation in pancreas, liver and skeletal muscle in patients with obesity, overweight and normal BMI in correlation with the presence of central obesity and metabolic syndrome. Diabetes Metab. Tabak, A. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study.
A prospective study of the temporal changes in metabolic function and glucose control along the natural history of T2DM. Weir, G. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 53 Suppl. Google Scholar.
Astrup, A. Leitner, D. Obesity and type 2 diabetes: two diseases with a need for combined treatment strategies — EASO can lead the way. Facts 10 , — Sjostrom, L. Review of the key results from the Swedish Obese Subjects SOS trial — a prospective controlled intervention study of bariatric surgery. Jans, A. Duration of type 2 diabetes and remission rates after bariatric surgery in Sweden — a registry-based cohort study.
PLoS Med. Davies, M. Efficacy of liraglutide for weight loss among patients with type 2 diabetes: the SCALE diabetes randomized clinical trial. JAMA , — Madsbad, S. GLP-1 as a mediator in the remission of type 2 diabetes after gastric bypass and sleeve gastrectomy surgery. Diabetes 63 , — MacDonald, P. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes 51 Suppl. Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity.
Cell Metab. A randomized controlled trial of the effects of progressive diet-induced weight loss on body composition and metabolic function. Wing, R. Long-term effects of modest weight loss in type II diabetic patients. Henry, R. Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus. Diabetes 35 , — Markovic, T. Diabetes Care 21 , — Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus.
Hughes, T. Effects of caloric restriction and weight loss on glycemic control, insulin release and resistance, and atherosclerotic risk in obese patients with type II diabetes mellitus. Steven, S. Restoring normoglycaemia by use of a very low calorie diet in long- and short-duration type 2 diabetes. Lim, E. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 54 , — Taylor, R.
Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for beta cell recovery. Al-Mrabeh, A. Hepatic lipoprotein export and remission of human type 2 diabetes after weight loss. A prospective study evaluating the potential mechanisms of T2DM remission and relapse following lifestyle modification.
Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia 51 , — Can type 2 diabetes be reversed and how can this best be achieved? James Lind Alliance research priority number one.
Physical activity is a strong toll to prevent and treatment of T2D. With regard to the articles selected for this review, it can be said that all three types of physical activity AT, RT and CT affect the metabolic syndrome. But the CT seems to be more effective. Unfortunately, information about the effects of varied intensities and durations of CT on metabolic syndrome is limited. Type 2 Diabetes T2D is a metabolic disease that is brought about by either insufficient production of insulin or the inability of the body to respond to the insulin formed within the system. Obesity and lack of physical activity are two of the most common causes of this form of diabetes 1. The prevalence of T2D is increasing worldwide in the 21 st century 2.
Regular exercise is considered a cornerstone in the management of type 2 diabetes mellitus T2DM. It improves glucose control and cardiovascular risk factors, contributes to weight loss, and also improves general well-being, likely playing a role in the prevention of chronic complications of diabetes. However, compliance to exercise recommendations is generally inadequate in subjects with T2DM. Walking is the most ancestral form of physical activity in humans, easily applicable in daily life. It may represent, in many patients, a first simple step towards lifestyle changes. Nevertheless, while most diabetic patients do not engage in any weekly walking, exercise guidelines do not generally detail how to improve its use.
in type 2 diabetes showing: 1) effectiveness of exercise in reducing. HbA1c, independent of body weight; and 2) association between exercise training intensity.
Thank you for visiting nature.
Exercise is regarded as a front-line therapy for the prevention and treatment of type 2 diabetes and its many complications. Recent studies have shown that the addition or incorporation of resistance training to traditional continuous moderate-intensity exercise training e. There is also growing interest in the application of high-intensity interval training, which can be accomplished via interval walking in people with type 2 diabetes, for prevention and treatment of type 2 diabetes. In addition, the mechanisms by which exercise improves glucose control, reduces type 2 diabetes-related metabolic dysfunction, and lowers cardiovascular disease risk in people with prediabetes and type 2 diabetes have not been clearly elucidated. This Research Topic will highlight how different exercise strategies impact glucose control, metabolic function, and cardiometabolic risk factors in people with, and at risk for, type 2 diabetes. We encourage interested scientists, clinicians, and exercise specialists to submit mini-reviews, methods papers, review articles, perspectives, and original research articles covering this diverse topic.
This article is not configured properly for members or paid content. Discover easy-to-read, research-based articles that take your training knowledge further with Nutrition, Programming, and Personal Business Development columns in each quarterly, electronic issue. American Diabetes Association. Diagnosing diabetes and learning about prediabetes. StaRendards of medical care in diabetes —
И снова Стратмор нетерпеливым взмахом руки заставил ее замолчать.
- Почему. Стратмор сощурил. - А ты как думаешь.
Беккер остановился. Тупик. Стоя возле креста, он слушал, как приближаются шаги Халохота, смотрел на распятие и проклинал судьбу. Слева послышался звон разбитого стекла.
А на этот рейс были свободные места. - Сколько угодно, - улыбнулась женщина.
Your email address will not be published. Required fields are marked *