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Self Eating And Self Killing Crosstalk Between Autophagy And Apoptosis Pdf

self eating and self killing crosstalk between autophagy and apoptosis pdf

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What is the underlying mechanism of Sertoli cell SC resistance to cell death? High expression of prosurvival B-cell lymphoma-2 BCL2 proteins and inhibition of apoptosis and autophagy prolongs SC survival upon exposure to stress stimuli.

Box , Dept. Autophagy and apoptosis are catabolic pathways essential for organismal homeostasis. Autophagy is normally a cell-survival pathway involving the degradation and recycling of obsolete, damaged, or harmful macromolecular assemblies; however, excess autophagy has been implicated in type II cell death.

Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis

The functional relationship between apoptosis 'self-killing' and autophagy 'self-eating' is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death and suppresses apoptosis , whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses. Abstract The functional relationship between apoptosis 'self-killing' and autophagy 'self-eating' is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death and suppresses apoptosis , whereas in other cellular settings, it constitutes an alternative cell-death pathway. Publication types Research Support, Non-U. Gov't Review.

Self-consumption: the interplay of autophagy and apoptosis

The functional relationship between apoptosis 'self-killing' and autophagy 'self-eating' is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death and suppresses apoptosis , whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses. Nature Reviews. Molecular Cell Biology. Maria Chiara Maiuri Guido Kroemer. Get PDF.

Role of the Crosstalk between Autophagy and Apoptosis in Cancer

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Important User Information: Remote access to EBSCO's databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use. However, remote access to EBSCO's databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution. Sep, Vol.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of cells within organisms, respectively, and many stress pathways sequentially elicit autophagy, and apoptosis within the same cell.

Self-eating and self-killing: crosstalk between autophagy and apoptosis.

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5 Comments

  1. Actophanap

    03.05.2021 at 11:00
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    Autophagy involves degradation of dysfunctional cellular components through the actions of lysosomes.

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    06.05.2021 at 00:55
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    International Journal of Medical Sciences.

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  4. Donaldo B.

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    The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-.

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